Dimethyl Sulfoxide
Apexbio Technology LLC Cyclophosphamide 50-18-0 10mM (in 1mL DMSO)
Cyclophosphamide is a nitrogen mustard alkylating prodrug activated via hepatic enzymes to its active metabolites These metabolites alkylate DNA primarily at guanine residues resulting in DNA cross-linking strand breaks and mutations consequently triggering cytotoxic effects Cyclophosphamide exhibits cytotoxicity in vitro with an IC50 of 37 6 M in mouse embryo BALB/c 3T3 cells and an IC50 of 8 79 M against human HL60 cells It impacts immune regulation by decreasing regulatory T cell counts and suppressive marker expression (FoxP3 GITR) facilitating immune response modulation Commonly applied in cancer and immunological research cyclophosphamide is also employed in genotoxicity assays due to its capacity to induce chromosomal aberrations and mutations
Apexbio Technology LLC Pioglitazone HCl 112529-15-4 10mM (in 1mL DMSO)
Pioglitazone HCl is a potent and highly selective agonist of the peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor involved in glucose and lipid metabolism regulation Acting via PPAR activation pioglitazone increases insulin sensitivity in hepatic adipose and peripheral tissues enhancing insulin-mediated glucose uptake and utilization Pioglitazone requires the presence of insulin to exert its biological activity through receptor activation limiting its application in scenarios characterized by substantial insulin deficiency Clinically pioglitazone HCl has been widely applied in the management and investigation of hyperglycemia associated with type 2 diabetes mellitus (T2DM) Additionally pioglitazone demonstrates effects on lipid regulation notably reducing triglyceride levels and increasing high-density lipoprotein (HDL) cholesterol making it useful in metabolic research
Apexbio Technology LLC IOX2(Glycine) 931398-72-0 10mM (in 1mL DMSO)
IOX2(Glycine) (CAS 931398-72-0) is a selective inhibitor targeting hypoxia-inducible factor-prolyl hydroxylase-2 (PHD2) a key enzyme regulating oxygen sensing by mediating hydroxylation of HIF-1 IOX2 exhibits high target specificity demonstrating an IC50 of approximately 21 nM against PHD2 in vitro and negligible inhibition (over 100-fold selectivity) toward related enzymes such as JMJD2 isoforms and the 2OG-oxygenase FIH In RCC4 cells IOX2 at 50 M effectively suppresses HIF-1 hydroxylation highlighting its utility as a pharmacological probe in studying hypoxia signaling pathways and oxygen-dependent cellular responses
Apexbio Technology LLC Aloperine 56293-29-9 10mM (in 1mL DMSO)
Aloperine is a naturally derived alkaloid known for its biological properties including anti-inflammatory antiviral antibacterial and antitumor activities Mechanistic studies suggest that aloperine exerts anti-inflammatory effects through inhibition of inflammatory mediators and inflammatory signaling pathways such as nuclear factor-kappa B (NF- B) and mitogen-activated protein kinase (MAPK) pathways In vitro assays demonstrate antiviral potential related to inhibition of specific viral replication stages Additionally its antitumor properties have been identified in multiple cancer cell lines where aloperine can induce apoptosis inhibit proliferation and migration and modulate cell cycle progression Aloperine typically exhibits IC50 values ranging from low micromolar to sub-micromolar concentrations depending on cell lines and experimental settings It serves as a research tool compound in immunological oncological and infectious disease studies
Cayman Chemical L-MethIonIn SulfoxIde 25g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Apexbio Technology LLC Embelin 550-24-3 10mM (in 1mL DMSO)
Embelin (CAS 550-24-3) is a natural benzoquinone derivative isolated from plants of the genus Embelia functioning as an inhibitor of X-linked inhibitor of apoptosis protein (XIAP) with an IC50 value of 4 1 M XIAP negatively regulates apoptosis by inhibiting caspase activation Embelin promotes apoptosis by interrupting XIAP-caspase interaction activating apoptotic pathways in tumor cells expressing elevated XIAP levels Additionally embelin can inhibit the NF- B signaling cascade through suppression of IKK activation thereby downregulating NF- B-mediated anti-apoptotic and metastatic gene expression In animal models embelin demonstrates anti-tumor properties by attenuating tumorigenesis related to inflammation-driven colorectal cancer through modulation of IL-6/STAT3 pathway signaling
Crescent Chemical Co Inc DIMETHYL SULFOXIDE
Dimethyl sulfoxide research grade Highly active solvent and pharmaceutical vehicle; for freezing cells. For gradient centrifugation (1). Determination of cysteine and cystine in proteins (2). Size - 250ML Storage Conditions - +15 °C TO +30 °C Catalog
Apexbio Technology LLC CP-724714 537705-08-1 10mM (in 1mL DMSO)
CP-724714 (CAS 537705-08-1) is a small molecule inhibitor selectively targeting erbB2 (Her2) and EGFR kinases with notable potency against erbB2 kinase (IC50 10 3 nM) and considerably lower activity toward EGFR kinase (IC50 6 400 2 100 nM) In cellular assays CP-724714 induces G1 cell-cycle arrest and decreases erbB2 phosphorylation in Her2-overexpressing BT-474 breast cancer cells In animal xenograft models (BT-474 MDA-MB-453) it reduces erbB2 receptor phosphorylation and downstream signaling resulting in tumor growth inhibition and apoptosis induction CP-724714 advanced into phase I clinical trials for Her2-driven breast cancer research