Dimethyl Sulfoxide
Apexbio Technology LLC PF-670462 950912-80-8 10mM (in 1mL DMSO)
PF-670462 (CAS 950912-80-8) is a selective inhibitor of casein kinase 1 (CK1) isoforms CK1 and CK1 serine/threonine kinases involved in circadian rhythm regulation It exhibits inhibitory activity toward CK1 and CK1 with IC50 values of approximately 80 nM and 13 nM respectively In cellular models co-transfected with GFP-tagged PER3 and human CK1 PF-670462 blocks nuclear translocation of PER3 In primary fibroblasts from wild-type mice it dose-dependently prolongs circadian cycle length PF-670462 serves as a useful chemical tool for studying CK1-mediated modulation of circadian rhythms
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 2.5L
Dimethyl sulfoxide | Purity: ≥99.9% | MW:78.13 | 67-68-5 | MFCD00002089 | 2.5L
Apexbio Technology LLC Erythritol 149-32-6 10mM (in 1mL DMSO)
Erythritol (CAS 149-32-6) is a four-carbon polyol commonly studied for applications as a low-calorie sweetener Structurally related to other sugar alcohols it exhibits minimal caloric contribution due to limited systemic metabolism and absorption Mechanistically erythritol provides sweetness by interacting with taste receptors on the tongue but it does not significantly elevate blood glucose or insulin levels making it a relevant compound for diabetes and metabolic research Emerging evidence also suggests potential effects on gut microbiota and vascular health warranting exploration in biomedical studies focused on metabolism and cardiovascular function
Apexbio Technology LLC INCB28060 1029712-80-8 10mM (in 1mL DMSO)
INCB28060 (CAS 1029712-80-8) also known as Capmatinib or INC280 is an ATP-competitive inhibitor of the receptor tyrosine kinase c-Met (HGFR) This receptor plays essential roles in cellular processes including embryogenesis healing proliferation invasion and angiogenesis and is frequently overexpressed or mutated in cancers INCB28060 blocks c-Met phosphorylation and downstream signaling exhibiting an IC50 of 0 13 nM In preclinical studies it suppresses proliferation in cancer cell lines (e g SNU-5 S114) and inhibits migration in U-87MG and H441 cells In mouse tumor models oral administration reduces c-Met activation and tumor progression INCB28060 serves as a tool compound for investigating c-Met function in cancer research
Apexbio Technology LLC Griseofulvin 126-07-8 10mM (in 1mL DMSO)
Griseofulvin is an antifungal antibiotic known to inhibit fungal growth by interfering with microtubule polymerization thereby disrupting mitotic spindle formation and cellular division Through binding to tubulin it stabilizes microtubule structures preventing their normal assembly and leading to impaired fungal cell replication Experimentally Griseofulvin has been frequently utilized to study microtubule dynamics mitotic processes and antifungal mechanisms in research settings involving medically relevant fungi including dermatophytes Reported IC50 values for Griseofulvin range approximately from 5 to 20 M depending on fungal strains and conditions tested serving as a guideline for establishing antifungal assays and investigating fungal response mechanisms in vitro
TARGETMOL CHEMICALS INC TRAMETINIB DMSO SOLVATE 200MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 2 nM)purity: 99%
Apexbio Technology LLC Tetrahydrozoline HCl 522-48-5 10mM (in 1mL DMSO)
Tetrahydrozoline HCl (CAS 522-48-5) is an imidazoline-based small molecule that functions primarily as an agonist at alpha-adrenergic receptors Activation of these receptors by tetrahydrozoline elicits vasoconstriction via smooth muscle contraction reducing redness and swelling Due to this mechanism tetrahydrozoline hydrochloride is commonly utilized as a research tool to investigate alpha receptor-mediated physiological and pharmacological responses particularly in cardiovascular and ocular experimental models
Gold Biotechnology Inc Sterile Filtered DMSO
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Apexbio Technology LLC GYY 4137 morpholine salt(Synonyms: GYY4137, Morpholin-4-ium 4-methoxyphenyl(morpholino)phosphinodithioate, GYY-4137), 10mM (in 1mL DMSO), CAS: 106740-09-4.
GYY 4137 morpholine salt (CAS 106740-09-4) is a slow-releasing hydrogen sulfide (H S) donor that exerts biological activity by modulating signaling pathways involved in vasodilation and blood pressure regulation In experimental studies this compound demonstrates the capacity to suppress cellular proliferation induce apoptosis and arrest cell cycle progression Due to these properties GYY 4137 morpholine salt is widely utilized in research investigating hypertension inflammation and cancer biology
Apexbio Technology LLC Ro3280 1062243-51-9 10mM (in 1mL DMSO)
Ro3280 (CAS 1062243-51-9) is a selective small-molecule inhibitor targeting Polo-like kinase 1 (PLK1) exerting inhibitory activity with an IC50 of 3 nM PLK1 is a cell cycle kinase involved prominently in regulating progression from G2 to M phase frequently overexpressed in various malignancies Ro3280 inhibits PLK1 activity and induces apoptosis and cell cycle disruption in acute leukemia cell lines (e g U937 HL-60 NB4 K562 MV4-11) and diverse solid tumor models (e g lung carcinoma H82 colon carcinoma HT-29 breast carcinoma MDA-MB-468) In mouse xenografts of HT-29 tumors Ro3280 demonstrates significant tumor regression highlighting its potential in cancer therapeutics research
Apexbio Technology LLC Phenacetin 62-44-2 10mM (in 1mL DMSO)
Phenacetin (CAS 62-44-2) is a synthetic non-opioid analgesic historically utilized for alleviating pain and reducing fever lacking intrinsic anti-inflammatory effects Its analgesic mechanism primarily involves inhibition of cyclooxygenase (COX) enzyme activity in the central nervous system leading to decreased prostaglandin synthesis Previously studied for its pharmacological action on pain modulation pathways phenacetin serves currently as an experimental reference compound in evaluating nephrotoxic effects in biomedical research following its market withdrawal due to nephropathy concerns
U.S. Pharmacopeia Dimethyl Sulfoxide, 67-68-5, MFCD00002089, 3g
Molecular formula C2H6OS, Molecular weight 78.13, Melting Point 64.4 - 66.2 °F (18 - 19 °C), Boiling Point 372.2 °F (189 °C), Synonyms: DMSO, Methyl sulfoxide
Apexbio Technology LLC WAY-600 1062159-35-6 10mM (in 1mL DMSO)
WAY-600 is an ATP-competitive inhibitor targeting mammalian target of rapamycin (mTOR) specifically inhibiting the phosphorylation activity mediated by mTOR complexes It suppresses mTORC1 signaling via inhibition of phosphorylation of ribosomal S6 kinase (S6K) at Thr389 and attenuates mTORC2 signaling by inhibiting phosphorylation of protein kinase B (AKT) at Ser473 Importantly WAY-600 does not interfere with AKT phosphorylation at Thr308 The compound demonstrates marked selectivity for mTOR over phosphatidylinositol 3-kinase (PI3K) isoforms displaying greater than 100-fold selectivity against PI3K and over 500-fold selectivity against PI3K WAY-600 represents a valuable tool for investigating mTOR-dependent signaling pathways metabolism regulation cellular proliferation autophagy and related oncological and metabolic research areas
Apexbio Technology LLC Bepotastine Besilate 190786-44-8 10mM (in 1mL DMSO)
Bepotastine Besilate (CAS number 190786-44-8) is a small molecule antagonist targeting the histamine H1 receptor By binding selectively to this receptor subtype Bepotastine attenuates histamine-induced cellular responses decreasing symptoms associated with allergic reactions In experimental settings it serves as a pharmacological tool to investigate histamine-related inflammatory pathways and receptor signaling mechanisms Its utility extends to studies of allergic responses inflammation modulation and histamine receptor pharmacodynamics in biomedical research
Medchemexpress LLC Toltrazuril sulfoxide | 69004-15-5 | MFCD10567359 | 99.6% | C18H14F3N3O5S | 10MG
Toltrazuril sulfoxide is an analytical standard corresponding to the short-lived sulfoxide metabolite of toltrazuril. It is intended for research and analytical applications, including metabolic studies, method development, and quantitative analysis of toltrazuril metabolites.
- Analytical standard suitable for metabolic and pharmacokinetic studies.
- High purity (99.6%) for reliable analytical results.
- Provided in small pack sizes for trace-level assays and method validation.
- Compatible with LC-MS and other chromatographic detection methods.
- Stable solid form for routine storage and handling.