Dimethyl Sulfoxide
Apexbio Technology LLC Doxercalciferol 54573-75-0 10mM (in 1mL DMSO)
Doxercalciferol chemically known as 1 -Hydroxyvitamin D2 is a synthetic analog of vitamin D2 characterized by selective activation of the vitamin D receptor (VDR) Upon metabolic activation Doxercalciferol undergoes hepatic transformation to its biologically active form inducing gene transcription mediated via the VDR signaling pathway Central to its mechanism activated VDR regulates calcium and phosphate homeostasis influencing cellular differentiation proliferation and parathyroid hormone expression In biomedical research Doxercalciferol serves as a tool compound to investigate the molecular pathways regulated by vitamin D receptor activation particularly in renal insufficiency models bone metabolism studies and parathyroid physiology experiments
Apexbio Technology LLC Methotrexate 59-05-2 10mM (in 1mL DMSO)
Methotrexate is a folate antagonist commonly utilized in biomedical research due to its inhibitory action on dihydrofolate reductase (DHFR) a critical enzyme in folate metabolism This inhibition disrupts nucleotide synthesis thereby interfering with cell proliferation Upon cell uptake methotrexate is converted intracellularly into polyglutamate derivatives which prolong its biochemical activity through sustained enzyme inhibition Additionally methotrexate promotes extracellular adenosine release at inflammatory sites mediating immunological effects In cellular assays for DHFR inhibition methotrexate demonstrates potent inhibitory activity with reported IC50 values typically ranging from 5 to 50 nM depending on the cell type and experimental conditions Methotrexate is widely utilized in research on inflammation oncology and rheumatoid arthritis-related mechanisms
Apexbio Technology LLC MK-8776 (SCH-900776) 891494-63-6 10mM (in 1mL DMSO)
MK-8776 (SCH-900776 CAS number 891494-63-6) is a selective small molecule inhibitor targeting the serine/threonine kinase checkpoint kinase 1 (Chk1) Chk1 is involved in detecting DNA damage and regulating DNA replication particularly in stabilizing replication forks during genotoxic stress SCH-900776 selectively inhibits Chk1 activity (IC50 3 nM) over Chk2 and Cdk3 In cellular assays SCH-900776 treatment results in dose-dependent inhibition of Chk1 autophosphorylation at Ser296 accompanied by increased phosphorylation at Ser345 a cellular marker consistent with checkpoint disruption In preclinical models combining SCH-900776 with DNA-damaging agents such as gemcitabine enhances anti-tumor efficacy marking its potential utility in cancer research
Apexbio Technology LLC RK-33 1070773-09-9 10mM (in 1mL DMSO)
RK-33 is a small molecule inhibitor targeting DDX3 an RNA helicase frequently overexpressed in various cancer types including lung cancer DDX3 overexpression correlates with poorer survival outcomes in lung cancer patients suggesting therapeutic relevance Mechanistically RK-33 inhibits DDX3 enzymatic activity thereby disrupting downstream signaling pathways particularly the -catenin-dependent Wnt signaling axis In vitro studies indicate RK-33 induces cell cycle arrest at G1 phase promotes apoptosis and enhances cellular radiosensitivity in DDX3-high expressing cell lines (e g A549 H1299 H23 and H460 IC50 4 4 8 4 M) In preclinical in vivo testing using a Twist1/KrasG12D mouse lung cancer model combined treatment of RK-33 with radiation resulted in reduced tumor growth compared with radiation alone RK-33 serves as a research tool to investigate DDX3 biology and potential therapeutic strategies for cancers with elevated DDX3 expression
Apexbio Technology LLC Gemfibrozil 25812-30-0 10mM (in 1mL DMSO)
Gemfibrozil is a small-molecule pharmacological agent that functions primarily through activation of the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR ) By modulating PPAR signaling pathways gemfibrozil regulates lipid metabolism influencing the transcription of genes associated with fatty acid oxidation and lipoprotein synthesis resulting in reduced triglyceride levels and altered lipoprotein profiles In biomedical research contexts gemfibrozil is utilized to explore molecular mechanisms underlying lipid metabolic processes atherosclerosis progression and related metabolic disorders Furthermore gemfibrozil serves as a useful experimental tool to dissect PPAR -dependent pathways and to investigate therapeutic potentials targeting lipid abnormalities and cardiovascular disease
Apexbio Technology LLC Silymarin 22888-70-6 10mM (in 1mL DMSO)
Silymarin (CAS 22888-70-6) is a naturally occurring flavonoid complex derived from the seeds of plants belonging to the Asteraceae family notably milk thistle (Silybum marianum) This phytochemical mixture exerts cellular antioxidant and anti-inflammatory activities primarily by inhibiting lipid peroxidation scavenging free radicals stabilizing cell membranes and modulating intracellular signaling pathways linked to oxidative stress response In biomedical research silymarin is extensively studied for hepatoprotective properties and its potential applications in investigating liver injury hepatotoxicity models and oxidative stress-mediated cellular damage The compound can be appropriately dissolved in solvents such as methanol ethanol acetone or ethyl acetate and requires storage under dry cool and sealed conditions
Apexbio Technology LLC SAR245409 (XL765) 1349796-36-6 10mM (in 1mL DMSO)
SAR245409 (XL765 CAS 1349796-36-6) is a selective dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with high potency against PI3K (IC50 9 nM) It suppresses the PI3K/Akt/mTOR signaling cascade by preventing formation of phosphatidylinositol-3 4 5-triphosphate (PIP3) at the cell membrane and downstream phosphorylation of AKT p70S6 kinase and S6 SAR245409 demonstrates antitumor activity in cancer models exhibiting genetic alterations in PI3K pathways enhancing growth suppression and apoptosis It is commonly employed in preclinical studies evaluating PI3K/mTOR-targeted approaches in cancer therapy
Apexbio Technology LLC RO5126766(CH5126766) 946128-88-7 10mM (in 1mL DMSO)
RO5126766 (CH5126766 CAS 946128-88-7) is a dual Raf/MEK inhibitor that targets the RAS/RAF/MEK/ERK signaling pathway involved in cellular proliferation survival and differentiation By inhibiting RAF-dependent MEK1 phosphorylation and subsequent MEK-mediated ERK activation RO5126766 suppresses downstream signaling In vitro kinase assays show IC50 values of 0 0082 0 056 M for MEK1 phosphorylation and 0 16 M for MEK1-induced ERK2 activation Studies in KRAS-mutant cancer cell lines such as HCT116 and NCI-H460 demonstrate that RO5126766 blocks MEK and ERK phosphorylation effectively inducing cell cycle arrest at the G1 stage Thus RO5126766 serves as a valuable research tool for investigating tumor biology driven by MAPK signaling dysregulation
Apexbio Technology LLC WZ4002 1213269-23-8 10mM (in 1mL DMSO)
WZ4002 (CAS 1213269-23-8) is an irreversible EGFR tyrosine kinase inhibitor that selectively targets mutant epidermal growth factor receptor (EGFR) variants It potently inhibits autophosphorylation of EGFR mutants including T790M L858R/T790M delE746 A750/T790M L858R and delE746 A750 at low nanomolar Ki values Compared to wild-type EGFR mutant EGFR demonstrates greater sensitivity to WZ4002 at lower concentrations limiting off-target toxicity in normal tissues WZ4002 serves as a research tool for studying EGFR-driven tumorigenesis and therapeutic resistance in oncology models
Medchemexpress LLC Ru.521 10Mm Dmso Solid 1Nl | HY-114180-10MM DMSO SOLID
Ru.521 10Mm Dmso Solid 1Nl
Apexbio Technology LLC MLN8237 (Alisertib) 1028486-01-2 10mM (in 1mL DMSO)
MLN8237 (Alisertib CAS 1028486-01-2) is an orally administered small molecule inhibitor targeting Aurora A kinase (AAK) an enzyme frequently overexpressed in various cancers and linked to tumor proliferation and progression Developed from its predecessor MLN8054 to reduce benzodiazepine-like side effects MLN8237 potently inhibits Aurora A kinase through reversible ATP-competitive binding (Ki 0 43 nmol/L) Given its demonstrated anti-tumor activity in preclinical in vitro and in vivo studies MLN8237 is currently under investigation for treating advanced malignancies
Apexbio Technology LLC JSH-23 749886-87-1 10mM (in 1mL DMSO)
JSH-23 (CAS 749886-87-1) is a small-molecule inhibitor of NF- B transcriptional activity exhibiting an IC50 of approximately 7 1 M Mechanistically JSH-23 prevents NF- B-mediated gene transcription by reducing nuclear localization and DNA binding activity of the NF- B p65 subunit without interfering with I B degradation In LPS-stimulated RAW 264 7 macrophages JSH-23 decreases expression of pro-inflammatory mediators including IL-6 IL-1 COX-2 and TNF- and inhibits apoptotic chromatin condensation This compound serves as a research tool for studying NF- B signaling and related inflammatory processes
Selleck Chemical LLC UBCS039, Solution 10mM (1mL in DMSO)
UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
Apexbio Technology LLC Vinorelbine 71486-22-1 10mM (in 1mL DMSO)
Vinorelbine is a semisynthetic vinca alkaloid derived from the plant Catharanthus roseus (L ) G Don Structurally characterized by its ability to bind selectively to tubulin this compound inhibits microtubule polymerization and disrupts mitotic spindle function leading to cell cycle arrest in metaphase and subsequent apoptosis Due to these antimitotic properties vinorelbine is extensively employed in biomedical research focused on investigating cell proliferation mechanisms understanding tumor biology and evaluating cytotoxicity profiles in vitro and in vivo Commonly utilized as a chemotherapy agent it serves as a research tool in studies of cancer pharmacology and drug resistance modeling Vinorelbine must be stored in a properly sealed container under cool dry conditions to maintain its chemical stability and biological activity for experimental use